Resources » Syndrome Description

Connective Tissue

Children with M-CM can have connective tissue abnormalities affecting the skin and joints.  Connective tissue is a scaffolding-type material that binds and supports the body.  It helps make up tendons, joints, ligaments, bones and cartilage.  There appears to be a connective tissue defect in M-CM.  The skin often feels soft, doughy and may appear loose, as if it is too large for the body.  Joints may be mildly loose or lax.  Joint dislocations have been described at birth.  The connective tissue aspects of M-CM are poorly understood and will hopefully be clarified over time.